Exploring new biosensing approaches based on light matter interactions

Exploring new biosensing approaches based on light matter interactions
IDM, Instituto Interuniversitario de Reconocimiento Molecular y Desarrollo Tecnológico, Departamento de Química, Universitat Politècnica de València. E-mail: vicgonpe@upvnet.upv.es
Nowadays, most clinical tests are based on time-consuming, expensive and sophisticated techniques performed by specialized technicians in laboratory environments. In this framework, there is a need to develop new point-of-care diagnosis approaches which meet the requirements of World Health Organization’s ASSURED criteria (Affordable, Sensitive, Specific, User-friendly, Rapid and robust, Equipment-free and Deliverable to end-users), enable personalized medicine, improve the efficiency of care and decrease costs, especially in resource-constrained settings where laboratory infrastructure is weak.
Here in this seminar, we first describe a low cost and easy-to-fabricate interferometric immusensor based on mesoporous 1D-photonic crystals composed of spin-coated multilayer stacks of SiO2 and TiO2 nanoparticles. The immunosensor presents sensitivities of 1.7 ± 0.15 nm/(mgL-1) (spectral shift) for the detection of streptavidin protein. As far as we know, our findings constitutes first report of a label free inmunosensor based on nanoparticle 1D photonic crystals and open new avenues towards the rational design of a new generation of versatile solution processed, cost-competitive and label-free biosensors.
In the second part of the seminar, we will inspect the advantages and shortcomings of CsPbX3 NCs as a new family of fluorogenic biomarkers in nanodiagnosis and biosensors field.